Bestatin
Cat. No.：YN250923
CAS No. ：58970-76-6
| 产品名称: | Bestatin |
| CAS No.: | 58970-76-6 |
| Chemical Name: | N-[(2S,3R)-3-amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucine |
| Synonyms: | 乌苯美司; Ubenimex |
| 分子量: | 308.37 |
| 分子式: | C₁₆H₂₄N₂O₄ |
| SMILES: | CC(C)C[C@@H](C(O)=O)NC([C@@H](O)[C@H](N)CC1=CC=CC=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bestatin (Ubenimex) 是CD13 (Aminopeptidase N)/APN和leukotriene A4 hydrolase抑制剂，常用于癌症研究。 |
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Umezawa, H., Ayoagi, T., Suda, H., et al.Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetesJ. Antibiot. (Tokyo)29(1),97-99(1976)
Melzig, M.F., and Bormann, H.Betulinic acid inhibits aminopeptidase N activityPlanta Med.64(7),655-657(1998)
Örning, L., Krivi, G., and Fitzpatrick, F.A.Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymesJ. Biol. Chem.266(3),1375-1378(1991)
Wang, X., Liu, Y., Liu, W., et al.Ubenimex, an APN inhibitor, could serve as an anti‑tumor drug in RT112 and 5637 cells by operating in an Akt‑associated mannerMol. Med. Rep.17(3),4531-4539(2018)
Zhao, S., Yao, K., Li, D., et al.Inhibition of LTA4H by bestatin in human and mouse colorectal cancerEBioMedicine44,361-374(2019)
