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Azaserine

Cat. No.:YN251167

  • CAS No. :115-02-6

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    • 产品名称: Azaserine
      CAS No.: 115-02-6
      Chemical Name: O-(2-diazoacetyl)-L-serine
      Synonyms:氮杂丝氨酸; CI-337; O-Diazoacetyl-L-serine; P-165
      分子量:173.13
      分子式:C₅H₇N₃O₄
      SMILES:N[C@@H](COC(C=[N+]=[N-])=O)C(O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Azazerine (CI-337) 是竞争性谷氨酰胺酰胺转移酶抑制剂。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Wise, D.R., and Thompson, C.B.Glutamine addiction: A new therapeutic target in cancerTrends Biochem. Sci.35(8),427-433(2010)

      Lyons, S.D., Sant, M.E., and Christopherson, R.I.Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemiaJ. Biol. Chem.265(19),11377-11381(1990)

      King, J.B., West, M.B., Cook, P.F., et al.A novel, species-specific class of uncompetitive inhibitors of γ-glutamyl transpeptidaseJ. Biol. Chem.284(14),9059-9065(2009)

      Rajapakse, A.G., Ming, X.F., Carvas, J.M., et al.The hexosamine biosynthesis inhibitor azaserine prevents endothelial inflammation and dysfunction under hyperglycemic condition through antioxidant effectsAm. J. Physiol. Heart Circ. Physiol.296(3),H815-H822(2009)

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