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Oxolinic acid

Cat. No.:YN251197

  • CAS No. :14698-29-4

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    • 生物活性
    • 参考文献
    • 产品名称: Oxolinic acid
      CAS No.: 14698-29-4
      Chemical Name: 5-ethyl-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid
      Synonyms:恶喹酸
      分子量:261.23
      分子式:C₁₃H₁₁NO₅
      SMILES:O=C(C1=CN(CC)C2=C(C=C3C(OCO3)=C2)C1=O)O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: Oxolinic acid 是DNA促旋酶和DNA合成的有效抑制剂。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Drlica, K., and Zhao, X.DNA gyrase, topoisomerase IV, and the 4-quinolonesMicrobiol. Mol. Biol. Rev.61(3),377-392(1997)

      Collin, F., Karkare, S., and Maxwell, A.Exploiting bacterial DNA gyrase as a drug target: Current state and perspectivesAppl. Microbiol. Biotechnol.92(3),479-497(2011)

      Hays, J.B., and Boehmer, S.Antagonists of DNA gyrase inhibit repair and recombination of UV-irradiated phage λProc. Natl. Acad. Sci. USA75(9),4125-4129(1978)

      Engle, E.C., Manes, S.H., and Drlica, K.Differential effects of antibiotics inhibiting gyraseJ. Bacteriol.149(1),92-98(1982)

      García de Mateos-Verchere, J., Vaugeois, J.M., Naudin, B., et al.Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitorEur. Neuropsychopharmacol.8(4),255-259(1998)

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