Oxolinic acid
Cat. No.：YN251197
| 产品名称: | Oxolinic acid |
| CAS No.: | 14698-29-4 |
| Chemical Name: | 5-ethyl-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid |
| Synonyms: | 恶喹酸 |
| 分子量: | 261.23 |
| 分子式: | C₁₃H₁₁NO₅ |
| SMILES: | O=C(C1=CN(CC)C2=C(C=C3C(OCO3)=C2)C1=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Oxolinic acid 是DNA促旋酶和DNA合成的有效抑制剂。 |
| IC50和靶点: | |
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Drlica, K., and Zhao, X.DNA gyrase, topoisomerase IV, and the 4-quinolonesMicrobiol. Mol. Biol. Rev.61(3),377-392(1997)
Collin, F., Karkare, S., and Maxwell, A.Exploiting bacterial DNA gyrase as a drug target: Current state and perspectivesAppl. Microbiol. Biotechnol.92(3),479-497(2011)
Hays, J.B., and Boehmer, S.Antagonists of DNA gyrase inhibit repair and recombination of UV-irradiated phage λProc. Natl. Acad. Sci. USA75(9),4125-4129(1978)
Engle, E.C., Manes, S.H., and Drlica, K.Differential effects of antibiotics inhibiting gyraseJ. Bacteriol.149(1),92-98(1982)
García de Mateos-Verchere, J., Vaugeois, J.M., Naudin, B., et al.Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitorEur. Neuropsychopharmacol.8(4),255-259(1998)
