Thonzonium bromide
Cat. No.:YN251268
| 产品名称: | Thonzonium bromide | 
| CAS No.: | 553-08-2 | 
| Chemical Name: | N-[2-[[(4-methoxyphenyl)methyl]-2-pyrimidinylamino]ethyl]-N,N-dimethyl-1-hexadecanaminium, monobromide | 
| Synonyms: | 通佐溴胺 | 
| 分子量: | 591.71 | 
| 分子式: | C₃₂H₅₅BrN₄O | 
| SMILES: | CCCCCCCCCCCCCCCC[N+](C)(CCN(CC1=CC=C(OC)C=C1)C2=NC=CC=N2)C.[Br-] | 
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. | 
| 运输: | Room temperature in continental US; may vary elsewhere. | 
| 产品描述: | Thonzonium bromide,一种结构上与 Farnesol (HY-Y0248A) 相似的抗菌剂,是一种单阳离子表面活性剂,在体外可抑制 RANKL 诱导的破骨细胞形成和骨吸收,并在体内阻止 LPS 诱导的骨丢失。Thonzonium bromide 以剂量依赖的方式抑制质子转运 (EC50=69 μM)。 | 
| IC50和靶点: | |
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Zhu, X., Gao, J.J., Landao-Bassonga, E., et al.Thonzonium bromide inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivoBiochem. Pharmacol.104,118-130(2016)
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