Nifuroxazide
Cat. No.：YN251319
CAS No. ：965-52-6
| 产品名称: | Nifuroxazide |
| CAS No.: | 965-52-6 |
| Chemical Name: | 4-hydroxy-benzoic acid, 2-[(5-nitro-2-furanyl)methylene]hydrazide |
| Synonyms: | 硝呋齐特 |
| 分子量: | 275.22 |
| 分子式: | C₁₂H₉N₃O₅ |
| SMILES: | O=C(N/N=C/C1=CC=C([N+]([O-])=O)O1)C2=CC=C(O)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Nifuroxazide 是STAT3的有效抑制剂，且具有抗癌和抗转移活性。 |
| IC50和靶点: | |
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Vanhoof, R., Coignau, H., Stas, G., et al.Evaluation of the in vitro activity of nifuroxazide on enteropathogenic microorganisms: Determination of bacteriostatic and bactericidal concentrations and disk susceptibilityActa Clin. Belg.36(3),126-129(1981)
Yang, L., Rybtke, M.T., Jakobsen, T.H., et al.Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitorsAntimicrob. Agents Chemother.53(6),2432-2443(2009)
Nelson, E.A., Walker, S.R., Kepich, A., et al.Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3Blood112(13),5095-5102(2008)
Yang, F., Hu, M., Lei, Q., et al.Nifuroxazide induces apoptosis and impairs pulmonary metastasis in breast cancer modelCell Death Dis.6(3),e1701(2015)
El-Far, Y.M., Elsherbiny, N.M., El-Shafey, M., et al.The interplay of the inhibitory effect of nifuroxazide on NF-κB/STAT3 signaling attenuates acetic acid-induced ulcerative colitis in ratsEnviron. Toxicol. Pharmacol.79,103433(2020)
