Oritavancin diphosphate
Cat. No.：YN251366
CAS No. ：192564-14-0
| 产品名称: | Oritavancin diphosphate |
| CAS No.: | 192564-14-0 |
| Chemical Name: | (4"R)-22-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-arabino-hexopyranosyl)-N3"-[(4'-chloro[1,1'-biphenyl]-4-yl)methyl]-vancomycin, diphosphate |
| Synonyms: | LY333328 diphosphate |
| 分子量: | 1989.09 |
| 分子式: | C₈₆H₁₀₃Cl₃N₁₀O₃₄P₂ |
| SMILES: | O[C@@H]1[C@@H](O[C@@](O[C@@H](C)[C@@H]2O)([H])C[C@]2(C)NCC3=CC=C(C4=CC=C(Cl)C=C4)C=C3)[C@@H](O[C@H](CO)[C@H]1O)OC5=C(OC6=CC=C([C@H]([C@H]7NC([C@H](NC)CC(C)C)=O)O)C=C6Cl)C=C([C@](NC([C@@H](NC7=O)CC(N)=O)=O)([H])C(N[C@](C8=O)([H])C9=CC%10=C(O)C=C9)=O)C=C5OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Oritavancin diphosphate (LY333328 diphosphate) 是一种新型半合成的糖肽抗生素, 可用于革兰氏阳性菌感染的研究。 |
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Jones, R.N., Barrett, M.S., and Erwin, M.E.In vitro activity and spectrum of LY333328, a novel glycopeptide derivativeAntimicrob. Agents Chemother.41(2),(1997)
Zhanel, G.G., Schweizer, F., and Karlowsky, J.A.Oritavancin: Mechanism of actionClin. Infect. Dis.54(Suppl 3),S214-S219(2012)
Belley, A., McKay, G.A.A., F.F., Sarmiento, I., et al.Oritavancin disrupts membrane integrity of Staphylococcus aureus and vancomycin-resistant enterococci to effect rapid bacterial killingAntimicrob. Agents Chemother.54(12),5369-5371(2010)
Mendes, R.E., Farrell, D.J., Sader, H.S., et al.Activity of oritavancin against Gram-positive clinical isolates responsible for documented skin and soft-tissue infections in European and US hospitals (2010-13)J. Antimicrob. Chemother.70(2),498-504(2015)
Boylan, C.J., Campanale, K., Iversen, P.W., et al.Pharmacodynamics of oritavancin (LY333328) in a neutropenic-mouse thigh model of Staphylococcus aureus infectionAntimicrob. Agents Chemother.47(5),1700-1706(2003)
Heine, H.S., Bassett, J., Miller, L., et al.Efficacy of oritavancin in a murine model of Bacillus anthracis spore inhalation anthraxAntimicrob. Agents Chemother.52(9),3350-3357(2008)
