Physcion
Cat. No.：YN251442
CAS No. ：521-61-9
规格
价格(RMB)
库存
| 产品名称: | Physcion |
| CAS No.: | 521-61-9 |
| Chemical Name: | 1,8-dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione |
| Synonyms: | 大黄素甲醚; Parietin; Rheochrysidin |
| 分子量: | 284.26 |
| 分子式: | C₁₆H₁₂O₅ |
| SMILES: | O=C1C2=C(C=C(C)C=C2O)C(C3=CC(OC)=CC(O)=C13)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Physcion (Parietin) 是从中药大黄中得到的蒽醌类物质，为 6-磷酸葡萄糖酸脱氢酶 (6-phosphogluconate dehydrogenase) 抑制剂，IC50和Kd值分别为 38.5 μM 和 26.0 μM。Physcion (Parietin) 具有通便、保肝、抗炎、抗菌、抗增殖、抗肿瘤作用。 |
| IC50和靶点: | |
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Chien, S.-C., Wu, Y.-C., and Chen, Z.-W.Naturally occurring anthraquinones: Chemistry and therapeutic potential in autoimmune diabetes.Evid. Based Complement. Altnernat. Med.2015:35757,(2015)
Lin, R., Elf, S., Shan, C., et al.6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signallingNat. Cell Biol.17(11),1484-1496(2015)
