Concanamycin A
Cat. No.：YN251563
CAS No. ：80890-47-7
| 产品名称: | Concanamycin A |
| CAS No.: | 80890-47-7 |
| Chemical Name: | (3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propen-1-yl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-3, |
| Synonyms: | 卡那霉素A; Antibiotic X 4357B; Concanamycin; X 4357B |
| 分子量: | 866.09 |
| 分子式: | C₄₆H₇₅NO₁₄ |
| SMILES: | C[C@H]([C@@](C[C@H]1O[C@@](O[C@H](C)[C@H]2OC(N)=O)([H])C[C@H]2O)(O[C@H](/C=C/C)[C@H]1C)O)[C@H](O)[C@@H]([C@](OC(/C(OC)=C/C(C)=C/[C@H]([C@@H](O)[C@H]3CC)C)=O)([H])[C@H](/C=C/C=C(C[C@H]([C@@H]3O)C)/C)OC)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Concanamycin A (Antibiotic X 4357B) 是一种大环内酯类抗生素，也是特异的空泡状 H+- ATP 酶(V-ATPase)抑制剂。 |
| IC50和靶点: | |
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Kinashi, H., Someno, K., and Sakahguchi, K.Isolation and characterization of concanamycins A, B and CJ. Antibiot. (Tokyo)37(11),1333-1343(1984)
Johnson, R.M., Allen, C., Melman, S.D., et al.Identification of inhibitors of V-ATPase pumps in yeast by HTS flow cytometryAnal. Biochem.398(2),203-211(2010)
Kataoka, T., Takaku, K., Magae, J., et al.Acidification is essential for maintaining the structure and function of lytic granules of CTL. Effect of concanamycin A, an inhibitor of vacuolar type H+-ATPase, on CTL-mediated cytotoxicityJ. Immunol.153(9),3938-3947(1994)
Guinea, R., and Carrasco, L.Requirement for vacuolar proton-ATPase activity during entry of influenza virus into cellsJ. Virol.69(4),2306-2312(1995)
