Oxaliplatin
Cat. No.：YN280098
CAS No. ：61825-94-3
| 产品名称: | Oxaliplatin |
| CAS No.: | 61825-94-3 |
| Chemical Name: | (SP-4-2)-[1R,2R-cyclohexanediamine-κN1,κN2][ethanedioato(2-)-κO1,κO2]-platinum |
| Synonyms: | 奥沙利铂 |
| 分子量: | 397.29 |
| 分子式: | C₈H₁₄N₂O₄Pt |
| SMILES: | O=C(O1)C(O[Pt]21[NH2][C@@H]3CCCC[C@H]3[NH2]2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Oxaliplatin 是一种DNA 合成抑制剂。Oxaliplatin 会导致 DNA 交联损伤，阻止 DNA 复制和转录并导致细胞死亡。Oxaliplatin 以时间依赖方式抑制人黑色素瘤细胞系 C32 和 G361，IC50值分别为 0.98 μM 和 0.14 μM。Oxaliplatin 可以诱导细胞自噬 (autophagy)。 |
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Alcindor, T., and Beauger, N.Oxaliplatin: A review in the era of molecularly targeted therapyCurr. Oncol.18(1),18-25(2011)
Rixe, O., Ortuzar, W., Alvarez, M., et al.Oxaliplatin, tetraplatin, cisplatin, and carboplatin: Spectrum of activity in drug-resistant cell lines and in the cell lines of the National Cancer Institute's Anticancer Drug Screen panelBiochem. Pharmacol.52(12),1855-1865(1996)
Wang, Z., Zhou, J., Fan, J., et al.Oxaliplatin induces apoptosis in hepatocellular carcinoma cells and inhibits tumor growthExpert Opin. Investig. Drugs18(11),1595-1604(2009)
