ULS 欢迎您!
ULS 欢迎您!
> 产品中心 > 抑制剂 & 激动剂 > Membrane Transporter/Ion Chann > Calcium Channel

Bepridil hydrochloride

Cat. No.:YN360130

  • CAS No. :68099-86-5

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: Bepridil hydrochloride
      CAS No.: 68099-86-5
      Chemical Name: β-[(2-methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)-1-pyrrolidineethanamine, monohydrochloride
      Synonyms:CERM 1978
      分子量:403.00
      分子式:C₂₄H₃₅ClN₂O
      SMILES:[H]Cl.CC(C)COCC(N1CCCC1)CN(C2=CC=CC=C2)CC3=CC=CC=C3
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: Bepridil hydrochloride (CERM 1978) 是一种钙离子通道 (calcium channel) 抑制剂,具有抗心绞痛的作用。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Singh, B.N.The mechanism of action of calcium antagonists relative to their clinical applicationsBr. J. Clin. Pharmacol.21(Suppl 2),109S-121S(1986)

      Perez-Reyes, E., Van Deusen, A.L., and Vitko, I.Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: Block by antihypertensives, antiarrhythmics, and their analogsJ. Pharmacol. Exp. Ther.328(2),621-627(2009)

      Iijima, K., Chinushi, M., Izumi, D., et al.Effect of bepridil in atrial fibrillation inducibility facilitated by vagal nerve stimulation. Prevention of vagal nerve activation-induced shortening of the atrial action potential durationCirc. J.74(5),895-902(2010)

      Sinha, N., and Sen, S.Predicting hERG activities of compounds from their 3D structures: Development and evaluation of a global descriptors based QSAR modelEur. J. Med. Chem.46(2),618-630(2011)

      Sogaard, R., Ljungstrom, T., Pedersen, K.A., et al.KCNQ4 channels expressed in mammalian cells: Functional characteristics and pharmacologyAm. J. Physiol. Cell Physiol.280(4),C859-C866(2001)

      Li, Y., Sato, T., and Arita, M.Bepridil blunts the shortening of action potential duration caused by metabolic inhibition via blockade of ATP-sensitive K+ channels and Na+-activated K+ channelsJ. Pharmacol. Exp. Ther.291(2),562-568(1999)

      Sato, T., Costa, A.D.T., Saito, T., et al.Bepridil, an antiarrhythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotectionJ. Pharmacol. Exp. Ther.316(1),182-188(2006)

    • 摩尔计算器
    • 稀释计算器
    摩尔浓度计算器方程 :
    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    计算

    质量 浓度 体积 分子量
    稀释计算器 :
    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
    • C1
      V1
      C2
      V2
    • 您最近查看的产品:
    相关产品


    ULS 的所有产品和服务仅用于科学研究,我们不为任何其他用途提供产品和服务(也不为任何个人提供产品和服务)Copyright © 2020-2021 ULS. All Rights Reserved. 备案号:粤ICP备2021013238号-1
    0.373236s