Opnurasib
Cat. No.：YN290733
CAS No. ：2653994-08-0
规格
价格(RMB)
库存
| 产品名称: | Opnurasib |
| CAS No.: | 2653994-08-0 |
| Chemical Name: | 1-[6-[(4R)-4-(5-chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro[3.3]hept-2-yl]-2-propen-1-one |
| Synonyms: | JDQ-443; NVP-JDQ443 |
| 分子量: | 526.0319 |
| 分子式: | C29H28ClN7O |
| SMILES: | CC1=C(C2=C(C=NN3)C3=CC(C)=C2Cl)C(C4=CC(C=NN5C)=C5C=C4)=NN1C6CC7(CN(C(C=C)=O)C7)C6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Opnurasib (JDQ-443) (NVP-JDQ443) 是一种口服有效和选择性的共价KRAS G12C抑制剂。Opnurasib 具有抗肿瘤活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Lorthiois, E., Gerspacher, M., Beyer, K.S., et al.JDQ443, a structurally novel, pyrazole-based, covalent inhibitor of KRASG12C for the treatment of solid tumorsJ. Med. Chem.65(24),16173-16203(2022)
