SR-3029
Cat. No.：YN450001
CAS No. ：1454585-06-8
规格
价格(RMB)
库存
| 产品名称: | SR-3029 |
| CAS No.: | 1454585-06-8 |
| Chemical Name: | N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-(4-morpholinyl)-9H-purin-6-amine |
| Synonyms: | SR3029 |
| 分子量: | 480.45 |
| 分子式: | C₂₃H₁₉F₃N₈O |
| SMILES: | FC1=CC(N2C=NC3=C(NCC4=NC5=CC=C(F)C(F)=C5N4)N=C(N6CCOCC6)N=C23)=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SR-3029 是一种有效的，ATP 竞争性的CK1δ和CK1ε的抑制剂，IC50值分别为 44 nM 和 260 nM，Ki均为 97 nM。 |
| IC50和靶点: | [{name:"CKIδ:44 nM (IC50)"},{name: "CDK6/cyclin D3:427 nM (IC50)"},{name: "CDK6/cyclin D1:428 nM (IC50)"},{name: "CDK4/cyclin D3:368 nM (IC50)"},{name: "CDK4/cyclin D1:576 nM (IC50)"},{name: "FLT3:3000 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Bibian, M., Rahaim, R.J., Choi, J.Y., et al.Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative propertiesBioorg. Med. Chem. Lett.23(15),4374-4380(2013)
Rosenberg, L.H., Lafitte, M., Quereda, V., et al.Therapeutic targeting of casein kinase 1δ in breast cancerSci. Transl. Med.7(318),318ra202(2015)
