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EPZ015666

Cat. No.：1616391-65-1

  • CAS No. ：1616391-65-1

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    • 产品名称: EPZ015666
      CAS No.: 1616391-65-1
      Chemical Name:
      Synonyms:GSK3235025
      分子量:383.44
      分子式:C₂₀H₂₅N₅O₃
      SMILES:O=C(NC[C@H](O)CN1CCC(C=CC=C2)=C2C1)C3=CC(NC4COC4)=NC=N3
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 0.98
    • Bissinger, E.M., Heinke, R., Sippl, W., et al.Targeting epigenetic modifiers: Inhibitors of histone methyltransferasesMed. Chem. Commun.1(2),(2010)', 'Copeland, R.A., Solomon, M.E., and Richon, V.M.Protein methyltransferases as a target class for drug discoveryNat. Rev. Drug Discov.8,724-732(2009)', 'Li, Y., Chitnis, N., Nakagawa, H., et al.PRMT5 is required for lymphomagenesis triggered by multiple oncogenic driversCancer Discov.5,288-303(2015)', 'Chung, J., Karkhanis, V., Tae, S., et al.Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) silencingJ. Biol. Chem.288(49),35534-35547(2013)', 'Chan-Penebre, E., Kuplast, K.G., Majer, C.R., et al.A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL modelsNat. Chem. Biol.11(6),432-437(2015)
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