Muramyl dipeptide
Cat. No.：YN350119
CAS No. ：53678-77-6
| 产品名称: | Muramyl dipeptide |
| CAS No.: | 53678-77-6 |
| Chemical Name: | N-(N-acetylmuramoyl)-L-alanyl-D-α-glutamine |
| Synonyms: | MDP |
| 分子量: | 492.48 |
| 分子式: | C₁₉H₃₂N₄O₁₁ |
| SMILES: | CC(N[C@@H]1[C@@H](OC(C(N[C@H](C(N[C@H](CCC(O)=O)C(N)=O)=O)C)=O)C)[C@H](O)[C@@H](CO)O[C@@H]1O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Muramyl dipeptide (MDP)，是一种合成的免疫反应肽 (immunoreactive peptide)，由 N-乙酰壁酸与 L-Ala-D-isoGln 的短氨基酸链相连。Muramyl dipeptide 是通过Runx2诱导骨形成的诱导因子。Muramyl dipeptide 通过MAPK途径上调 Runx2 基因表达，直接促进成骨细胞分化，通过降低 RANKL/OPG 比值间接抑制破骨细胞分化。Muramyl dipeptide 来自革兰氏阳性菌和革兰氏阴性菌的肽聚糖的共同结构基序 |
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Ogawa, C., Liu, Y.-J., and Kobayashi, K.S.Muramyl dipeptide and its derivatives: Peptide adjuvant in immunological disorders and cancer therapyCurr. Bioact. Compd.7(3),,180-197(2011)
Chedid, L., Parant, M., Lefrancher, P., et al.Enhancement of nonspecific immunity to Klebsiella pneumoniae infection by a synthetic immunoadjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine) and several analogsProc. Natl. Acad. Sci. USA74(5),2089-2093(1977)
