VX-11e
Cat. No.：YN350142
CAS No. ：896720-20-0
规格
价格(RMB)
库存
| 产品名称: | VX-11e |
| CAS No.: | 896720-20-0 |
| Chemical Name: | 4-[2-[(2-chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide |
| Synonyms: | VTX-11e, Vertex-11e |
| 分子量: | 500.35 |
| 分子式: | C₂₄H₂₀Cl₂FN₅O₂ |
| SMILES: | FC1=CC(Cl)=C(NC2=NC(C3=CNC(C(N[C@H](CO)C4=CC=CC(Cl)=C4)=O)=C3)=C(C)C=N2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | VX-11e 是一种高效的，具有选择性的，可口服的ERK抑制剂，Ki值 < 2 nM。 |
| IC50和靶点: | [{name:"ERK2:2 nM (Ki)"},{name: "GSK3:395 (Ki)"},{name: "AURA:540 (Ki)"},{name: "CDK2:852 (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Aronov, A.M., Tang, Q., Martinez-Botella, G., et al.Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational controlJ. Med. Chem.52(20),6362-6368(2009)
