XMD8-92
Cat. No.：YN350146
CAS No. ：1234480-50-2
| 产品名称: | XMD8-92 |
| CAS No.: | 1234480-50-2 |
| Chemical Name: | 2-[[2-ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one |
| Synonyms: | XMD 8-92 |
| 分子量: | 474.55 |
| 分子式: | C₂₆H₃₀N₆O₃ |
| SMILES: | CN(C1=O)C2=CN=C(N=C2N(C3=C1C=CC=C3)C)NC4=C(C=C(C=C4)N5CCC(CC5)O)OCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | XMD8-92 是一种选择性的ERK5/BMK1抑制剂，Kd为 80 nM。 |
| IC50和靶点: | [{name:"BMK1:80 nM (Kd)"},{name: "BRD4:190 nM (Kd)"}] |
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Yang, Q., Deng, X., Lu, B., et al.Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia proteinCancer Cell18(3),258-267(2010)
Erazo, T., Moreno, A., Ruiz-Babot, G., et al.Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complexMol. Cell Biol.33(8),1671-1686(2013)
Lin, E.C.K., Amantea, C.M., Nomanbhoy, T.K., et al.ERK5 kinase activity is dispensable for cellular immune response and proliferationProc. Natl. Acad. Sci. USA113(42),11865-11870(2016)
