XMD17-109
Cat. No.：YN350166
CAS No. ：1435488-37-1
| 产品名称: | XMD17-109 |
| CAS No.: | 1435488-37-1 |
| Chemical Name: | 11-cyclopentyl-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dihydro-5-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one |
| Synonyms: | ,XMD17-109 |
| 分子量: | 638.80 |
| 分子式: | C₃₆H₄₆N₈O₃ |
| SMILES: | O=C1C2=C(C=CC=C2)N(C3CCCC3)C4=NC(NC5=C(OCC)C=C(C(N6CCC(N7CCN(C)CC7)CC6)=O)C=C5)=NC=C4N1C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | XMD17-109 是一种特异性的ERK-5抑制剂，IC50值为 162 nM。 |
| IC50和靶点: | [{name:"ERK5:162 nM (IC50)"},{name: "LRRK2[G2019S]:339 nM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Deng, X., Elkins, J.M., Zhang, J., et al.Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-onesEur. J. Med. Chem.70,758-767(2013)
Elkins, J.M., Wang, J., Deng, X., et al.X-ray crystal structure of ERK5 (MAPK7) in complex with a specific inhibitorJ. Med. Chem.56(11),4413-4421(2013)
