Ulixertinib hydrochloride
Cat. No.：YN350171
CAS No. ：1956366-10-1
规格
价格(RMB)
库存
| 产品名称: | Ulixertinib hydrochloride |
| CAS No.: | 1956366-10-1 |
| Chemical Name: | 4-[5-chloro-2-[(1-methylethyl)amino]-4-pyridinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide, monohydrochloride |
| Synonyms: | BVD-523 hydrochloride; VRT752271 hydrochloride |
| 分子量: | 469.79 |
| 分子式: | C₂₁H₂₃Cl₃N₄O₂ |
| SMILES: | O=C(C1=CC(C2=CC(NC(C)C)=NC=C2Cl)=CN1)N[C@@H](C3=CC=CC(Cl)=C3)CO.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ulixertinib hydrochloride (BVD-523 hydrochloride) 是一种有效、可口服、高度选择性、ATP-竞争性、可逆、共价的ERK1/2抑制剂，对 ERK2 的IC50值 <0.3 nM。Ulixertinib hydrochloride 同时可抑制 ERK2 和 下游蛋白 RSK 的磷酸化。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ward, R.A., Colclough, N., Challinor, M., et al.Structure-guided design of highly selective and potent covalent inhibitors of ERK1/2J. Med. Chem.58(11),4790-4801(2015)
