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Astragaloside IV

Cat. No.:YN350228

  • CAS No. :84687-43-4

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    • 生物活性
    • 参考文献
    • 产品名称: Astragaloside IV
      CAS No.: 84687-43-4
      Chemical Name: (3β,6α,16β,20R,24S)-20,24-epoxy-16,25-dihydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl, β-D-glucopyranoside
      Synonyms:黄芪甙
      分子量:784.97
      分子式:C₄₁H₆₈O₁₄
      SMILES:O[C@H]1[C@H](O)[C@@H](O)[C@]([H])(O[C@@H]2C(C)(C)[C@@]([C@@H](O[C@]3([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C[C@]4([H])[C@@]56CC[C@@]7(C)[C@@]4(C)C[C@H](O)[C@]7([H])[C@]8(C)O[C@H](C(C)(O)C)CC8)([H])[C@]5(C6)CC2)OC1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Astragaloside IV 是从黄芪中分到的皂苷类物质,能够抑制ERK1/2和JNK的激活,在乳腺癌细胞 MDA-MB-231 中,能够下调(MMP)-2,(MMP)-9的信号通路。
      IC50和靶点:
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    • Ren, S., Zhang, H., Mu, Y., et al.Pharmacological effects of Astragaloside IV: A literature reviewJ. Tradit. Chin. Med.33(3),413-416(2013)

      Shang, L., Qu, Z., Sun, L., et al.Astragaloside IV inhibits adenovirus replication and apoptosis in A549 cells in vitroJ. Pharm. Pharmacol.63(5),688-694(2011)

      Li, L., Hou, X., Xu, R., et al.Research review on the pharmacological effects of astragaloside IVFundam. Clin. Pharmacol.31(1),17-36(2017)

      Zhang, W.-D., Chen, H., Zhang, C., et al.Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitroPlanta Med.72(1),4-8(2006)

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