Methylnissolin
Cat. No.：YN350250
CAS No. ：73340-41-7
| 产品名称: | Methylnissolin |
| CAS No.: | 73340-41-7 |
| Chemical Name: | 6aR,11aR-dihydro-9,10-dimethoxy-6H-benzofuro[3,2-c][1]benzopyran-3-ol |
| Synonyms: | Astrapterocarpan |
| 分子量: | 300.31 |
| 分子式: | C₁₇H₁₆O₅ |
| SMILES: | COC1=C2O[C@]3([H])[C@](COC4=CC(O)=CC=C34)([H])C2=CC=C1OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Methylnissolin (Astrapterocarpan) 是从黄芪 (Astragalus membranaceus) 中分离的，可以抑制血小板衍生生长因子 (PDGF)-BB 诱导的细胞增殖，IC50为 10 μM。 Methylnissolin 抑制 PDGF-BB 诱导的细胞外信号调节激酶 1/2 (ERIC1/2) 丝裂原活化蛋白 (MAP) 激酶的磷酸化。 Methylnissolin 通过抑制ERK1/2MAP 激酶级联反应抑制 PDGF-BB 诱导的血管平滑肌细胞增殖。 |
| IC50和靶点: | [{name:"PDGFR:10 μM (IC50)'}, 'ERK1', 'ERK2'] |
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| Solvent & Solubility: |
Onhawara, S., Okuma, Y., Uehara, T., et al.Astrapterocarpan isolated from Astragalus membranaceus inhibits proliferation of vascular smooth muscle cellsEur. J. Pharmacol.525(1-3),41-47(2005)
