Robotnikinin
Cat. No.：YN450156
| 产品名称: | Robotnikinin |
| CAS No.: | 1132653-79-2 |
| Chemical Name: | N-[(4-chlorophenyl)methyl]-5,12-dioxo-2R-phenyl-1-oxa-4-azacyclododec-8E-ene-6S-acetamide |
| Synonyms: | |
| 分子量: | 455 |
| 分子式: | C25H27ClN2O4 |
| SMILES: | O=C1[C@H](CC(NCC2=CC=C(Cl)C=C2)=O)C/C=C/CCC(O[C@@H](CN1)C3=CC=CC=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Robotnikinin 是一个能够结合和抑制 Smo上游SonicHedgehog(Shh)信号的小分子。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
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Stone, D.M., Hynes, M., Armanini, M., et al.The tumour-suppressor gene patched encodes a candidate receptor for sonic hedgehogNature384(6605),129-133(1996)
Rohatgi, R., Milenkovic, L., Corcoran, R.B., et al.Hedgehog signal transduction by smoothened: Pharmacologic evidence for a 2-step activation processProc. Natl. Acad. Sci. USA106(9),3196-3201(2009)
Stanton, B.Z., Peng, L.F., Maloof, N., et al.A small molecule that binds hedgehog and blocks its signaling in human cellsNat. Chem. Biol.5(3),154-156(2009)
Stanton, B.Z., and Peng, L.F.Small-molecule modulators of the Sonic Hedgehog signaling pathwayMol. Biosyst.6(1),44-54(2010)
