Betulinic acid
Cat. No.：YN370316
CAS No. ：472-15-1
| 产品名称: | Betulinic acid |
| CAS No.: | 472-15-1 |
| Chemical Name: | 3β-hydroxy-lup-20(29)-en-28-oic acid |
| Synonyms: | 白桦脂酸; Lupatic acid; Betulic acid |
| 分子量: | 456.70 |
| 分子式: | C₃₀H₄₈O₃ |
| SMILES: | [H][C@@]12CC[C@@]3(C)[C@]4(C)CC[C@]5(C(O)=O)[C@@]([C@H](C(C)=C)CC5)([H])[C@@](CC[C@@]([H])3[C@@]1(C)CC[C@H](O)C2(C)C)4[H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Betulinic acid 是一种天然的五环三萜类化合物，为真核细胞拓扑异构酶 I (topoisomerase I) 的抑制剂，IC50值为 5 μM，具有抗炎，抗疟疾，抗艾滋病和抗肿瘤等活性。Betulinic acid 也是一种新的NF-kB的激动剂。 |
| IC50和靶点: | [{name:"Topoisomerase I:5 μM (IC50)"},{name: "HIV-1:1.4 μM (EC50)'}, 'NF-κB'] |
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Genet, C., Strehle, A., Schmidt, C., et al.Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: Potential impact in diabetesJ. Med. Chem.53(1),178-190(2010)
Wan, Y., Jiang, S., Lian, L.H., et al.Betulinic acid and betulin ameliorate acute ethanol-induced fatty liver via TLR4 and STAT3 in vivo and in vitroInt. Immunopharmacol.17(2),184-190(2013)
Kashiwada, Y., Hashimoto, F., Cosentino, L.M., et al.Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agentsJ. Med. Chem.39(5),1016-1017(1996)
Zhao, G.J., Tang, S.L., Lv, Y.C., et al.Antagonism of betulinic acid on LPS-mediated inhibition of ABCA1 and cholesterol efflux through inhibiting nuclear factor-kappaB signaling pathway and miR-33 expressionPLoS One8(9),e474782(2013)
Mullauer, F.B., Kessler, J.H., and Medema, J.P.Betulin is a potent anti-tumor agent that is enhanced by cholesterolPLoS One4(4),(2009)
