Garcinol
Cat. No.：YN370375
| 产品名称: | Garcinol |
| CAS No.: | 78824-30-3 |
| Chemical Name: | (1R,5R,7R)-3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-bicyclo[3.3.1]non-3-ene-2,9-dione |
| Synonyms: | 山竹子素 |
| 分子量: | 602.80 |
| 分子式: | C₃₈H₅₀O₆ |
| SMILES: | C/C(C)=C\C[C@@H](C[C@]12C([C@](C(C)([C@@H](C2)C/C=C(C)\C)C)(C/C=C(C)\C)C(C(C(C3=CC(O)=C(C=C3)O)=O)=C1O)=O)=O)C(C)=C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Garcinol 是一种从印度藤黄提取的聚异戊二烯基二苯甲酮，对乙酰胆碱酯酶 (AChE) 和丁酰胆碱酯酶 (BChE) 具有抗胆碱酯酶的特性，IC50分别为 0.66 µM 和 7.39 µM。Garcinol 还抑制组蛋白乙酰转移酶 (HATs,IC50=7 μM) 和 p300/CPB 相关因子 (PCAF,IC50=5 μM)。Garcinol 具有抗炎和抗癌活性。 |
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Balasubramanyam, K., Altaf, M., Varier, R.A., et al.Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expressionJ. Biol. Chem.279(32),33716-33726(2004)
Koeberle, A., Northoff, H., and Werz, O.Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinolBiochem. Pharmacol.77(9),1513-1521(2009)
O'Meara, T.R., Hay, C., Price, M.S., et al.Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the hostEukaryot. Cell9(8),1193-1202(2010)
Yamaguchi, F., Saito, M., Ariga, T., et al.Free radical scavenging activity and antiulcer activity of garcinol from Garcinia indica fruit rindJ. Agric. Food Chem.48(6),2320-2325(2000)
Weng, M.-S., Liao, C.-H., Yu, S.-Y., et al.Garcinol promotes neurogenesis in rat cortical progenitor cells through the duration of extracellular signal-regulated kinase signalingJ. Agric. Food Chem.59(3),1031-1040(2011)
