C16-PAF
Cat. No.：YN370426
CAS No. ：74389-68-7
| 产品名称: | C16-PAF |
| CAS No.: | 74389-68-7 |
| Chemical Name: | 1-O-hexadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine |
| Synonyms: | PAF (C16) |
| 分子量: | 523.68 |
| 分子式: | C₂₆H₅₄NO₇P |
| SMILES: | CCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP(OCC[N+](C)(C)C)([O-])=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | C16-PAF (PAF (C16)) 是一种磷脂介质，是血小板活化因子，也是 PAF G 蛋白偶联受体 (PAFR) 的配体。C16-PAF 表现出抗凋亡作用，并通过激活 PAFR 来抑制 caspase 依赖性死亡。C16-PAF 诱导血管通透性增加。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Prescott, S.M., Zimmerman, G.A., and McIntyre, T.M.Platelet-activating factorJ. Biol. Chem.265(29),17381-17384(1990)
Carolan, E.J., and Casale, T.B.Degree of platelet activating factor-induced neutrophil migration is dependent upon the molecular speciesJ. Immunol.145,2561-2565(1990)
Rouis, M., Nigon, F., and Chapman, M.J.Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophagesBiochem. Biophys. Res. Commun.156,1293-1301(1988)
Thivierge, M., and Rola-Pleszczynski, M.Platelet-activating factor enhances interleukin-6 production by alveolar macrophagesJ. Allergy Clin. Immunol.90,796-802(1992)
Stewart, A.G., and Grigoriadis, G.Structure-activity relationships for platelet-activating factor (PAF) and analogs reveal differences between PAF receptors on platelets and macrophagesJ. Lipid Mediat.4(3),299-308(1991)
Wang, H., Tan, X.D., Qu, X.W., et al.Platelet-activating factor (PAF) up-regulates plasma and tissue PAF-acetylhydrolase activity in the rat: Effect of cycloheximidePediatr. Res.42,597-603(1997)
Sturk, A., Wouter Ten Cate, J., Hosford, D., et al.The synthesis, catabolism, and pathophysiological role of platelet-activating factorAdv. Lipid. Res.23,219-276(1989)
