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N1-Acetylspermidine hydrochloride

Cat. No.:YN370622

  • CAS No. :34450-16-3

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    • 参考文献
    • 产品名称: N1-Acetylspermidine hydrochloride
      CAS No.: 34450-16-3
      Chemical Name: N-[3-[(4-aminobutyl)amino]propyl]-acetamide, dihydrochloride
      Synonyms:N1-Acetylspermidine (hydrochloride)
      分子量:260.20
      分子式:C₉H₂₃Cl₂N₃O
      SMILES:CC(NCCCNCCCCN)=O.[H]Cl.[H]Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: N1-Acetylspermidine hydrochloride 是多胺的乙酰衍生物。N1-Acetylspermidine hydrochloride是多胺氧化酶 (PAO) 的底物。N1-Acetylspermidine hydrochloride 选择性升高人结直肠癌中的N1-乙酰亚精胺水平。N1-Acetylspermidine hydrochloride 在 DNA 的无嘌呤位点上具有一定的切割效率。
      IC50和靶点:
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    • Takao, K., Sugita, Y., and Shirahata, A.Assay of N1-acetylpolyamine oxidase activity with N1,N11-didansylnorspermine as the substrate by ion-pair reversed phase high performance liquid chromatographyBiol. Pharm. Bull.33(7),1089-1094(2010)

      Gawandi, V., and Fitzpatrick, P.F.The synthesis of deuterium-labeled spermine, N1-acetylspermine and N1-acetylspermidineJ. Labelled Comp. Radiopharm.50(7),666-670(2007)

      Gill, S.S., and Tuteja, N.Polyamines and abiotic stress tolerance in plantsPlant Signal. Behav.5(1),26-33(2010)

      Prunotto, M., Compagnone, A., Bruschi, M., et al.Endocellular polyamine availability modulates epithelial-to-mesenchymal transition and unfolded protein response in MDCK cellsLab Invest.90(6),929-939(2010)

      Babbar, N., Ignatenko, N.A., Casero, R.A., Jr., et al.Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancerJ. Biol. Chem.278(48),47762-47775(2003)

      Haukanes, B.I., Szajko, K., and Helland, D.E.Action of spermidine, N1-acetylspermidine, and N8-acetylspermidine at apurinic sites in DNAFEBS Lett.269(2),389-393(1990)

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