25-Hydroxycholesterol
Cat. No.：YN370654
CAS No. ：2140-46-7
| 产品名称: | 25-Hydroxycholesterol |
| CAS No.: | 2140-46-7 |
| Chemical Name: | cholest-5-ene-3β,25-diol |
| Synonyms: | 25-羟基胆固醇,25-羟基胆甾醇 |
| 分子量: | 402.65 |
| 分子式: | C₂₇H₄₆O₂ |
| SMILES: | CC(C)(O)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 25-Hydroxycholesterol 是胆固醇的代谢产物，由巨噬细胞响应 Toll 样受体 (TLR) 激活而产生和分泌。25-Hydroxycholesterol 有效且选择性抑制 B 细胞产生 IgA，EC50约为 65 nM。 |
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Adams, C.M., Reitz, J., De Brabander, J.K., et al.Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and InsigsJ. Biol. Chem.279(50),52772-52780(2004)
Cystger, J.G., Dang, E.V., Reboldi, A., et al.25-Hydroxycholesterols in innate and adaptive immunityNat. Rev. Immunol.14(11),731-743(2014)
Bauman, D.R., Bitmansour, A.D., McDonald, J.G., et al.25-Hydroxycholesterol secreted by macrophages in response to toll-like receptor activation suppresses immunoglobulin A productionProc. Natl. Acad. Sci. USA106(39),16764-16769(2009)
Zu, S., Deng, Y.-Q., Zhou, C., et al.25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitorCell Res.,1-3(2020)
