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2-Methylcitric acid

Cat. No.:YN370738

  • CAS No. :6061-96-7

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    • 产品名称: 2-Methylcitric acid
      CAS No.: 6061-96-7
      Chemical Name: 2-hydroxy-1,2,3-butanetricarboxylic acid
      Synonyms:Methylcitric acid
      分子量:206.15
      分子式:C₇H₁₀O₇
      SMILES:CC(C(O)=O)C(C(O)=O)(O)CC(O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: 2-Methylcitric acid (Methylcitric acid) 是 2- 甲基柠檬酸循环的内源性代谢物。2-Methylcitric acid 在甲基丙二酸血症和丙二酸酸血症中积累并能作为代谢标志物。2-Methylcitric acid 对谷氨酸支持的线粒体中 ADP 刺激和不耦合呼吸作用有明显的抑制作用。
      IC50和靶点:
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    • Allen, R.H., Stabler, S.P., Savage, D.G., et al.Elevation of 2-methylcitric acid I and II levels in serum, urine, and cerebrospinal fluid of patients with cobalamin deficiencyMetabolism42(8),978-988(1993)

      Al-Dirbashi, O.Y., McIntosh, N., and Chakraborty, P.Quantification of 2-methylcitric acid in dried blood spots improves newborn screening for propionic and methylmalonic acidemiasJ. Med. Screen.24(2),58-61(2017)

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