Cytarabine
Cat. No.：YN371673
| 产品名称: | Cytarabine |
| CAS No.: | 147-94-4 |
| Chemical Name: | 4-amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone |
| Synonyms: | 阿糖胞苷; Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C |
| 分子量: | 243.22 |
| 分子式: | C₉H₁₃N₃O₅ |
| SMILES: | O=C1N=C(N)C=CN1[C@H]2[C@H]([C@@H]([C@@H](CO)O2)O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cytarabine 是一种核苷类似物，可引起 S 期细胞周期停滞并抑制DNA聚合酶。Cytarabine 抑制DNA 合成的IC50为16 nM。Cytarabine 对HSV具有抗病毒作用。 |
| IC50和靶点: | |
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Li, Z., Guo, J.-R., Chen, Q.-Q., et al.Exploring the antitumor mechanism of high-dose cytarabine through the metabolic perturbations of ribonucleotide and deoxyribonucleotide in human promyelocytic leukemia HL-60 cellsMolecules22(3),E499(2017)
Emadi, A., and Karp, J.E.The clinically relevant pharmacogenomic changes in acute myelogenous leukemiaPharmacogenomics13(11),1257-1269(2012)
Qin, T., Youssef, E.M., Jelinek, J., et al.Effect of cytarabine and decitabine in combination in human leukemic cell linesClin. Cancer Res.13(14),4225-4232(2007)
Kelly, K.R., Espitia, C.M., Taverna, P., et al.Targeting PIM kinase activity significantly augments the efficacy of cytarabineBr. J. Haematol.156(1),129-132(2012)
Renis, H.E.Antiviral activity of cytarabine in Herpesvirus–infected ratsAntimicrob. Agents Chemother.4(4),439-444(1973)
