Ursodiol
Cat. No.：YN371787
| 产品名称: | Ursodiol |
| CAS No.: | 128-13-2 |
| Chemical Name: | (3α,5β,7β)-3,7-dihydroxy-cholan-24-oic acid |
| Synonyms: | 熊去氧胆酸; Ursodeoxycholic acid; UDCA |
| 分子量: | 392.57 |
| 分子式: | C₂₄H₄₀O₄ |
| SMILES: | C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ursodiol (Ursodeoxycholic acid; UDCA) 是一种有效的肝脏特异性脂肪酸转运蛋白 5 (FATP5) 抑制剂。Ursodiol 以 FATP5 依赖性方式抑制原代肝细胞摄取 LCFA。Ursodiol 可降低胆固醇的吸收，可用于溶解胆结石，并具有与肥胖相关的脂肪肝疾病研究的潜力。 |
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Deo, A.K., and Bandiera, S.M.3-Ketocholanoic acid is the major in vitro human hepatic microsomal metabolite of lithocholic acidDrug Metab. Dispos.37(9),1938-1947(2009)
Kim, R.B., Leake, B., Cvetkovic, M., et al.Modulation by drugs of human hepatic sodium-dependent bile acid transporter (sodium taurocholate cotransporting polypeptide) activityJ. Pharmacol. Exp. Ther.291(3),1204-1209(1999)
Rodrigues, C.M.P., Fan, G., Ma, X., et al.A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbationJ. Clin. Invest.101(12),2790-2799(1998)
