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5'-Methylthioadenosine

Cat. No.:YN372415

  • CAS No. :2457-80-9

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    • 参考文献
    • 产品名称: 5'-Methylthioadenosine
      CAS No.: 2457-80-9
      Chemical Name: 5'-S-methyl-5'-thio-adenosine
      Synonyms:5'-(Methylthio)-5'-deoxyadenosine; 5'-Deoxy-5'-(methylthio)adenosine; 5'-S-Methyl-5'-thioadenosine
      分子量:297.33
      分子式:C₁₁H₁₅N₅O₃S
      SMILES:O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3CSC
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: 5'-Methylthioadenosine 是由 S-腺苷酸产生的,有强效的抑制作用。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Huang, S.Histone methyltransferases, diet nutrients and tumour suppressorsNat. Rev. Cancer2(6),469-476(2002)

      Kehraus, S., Gorzalka, S., Hallmen, C., et al.Novel amino acid derived natural products from the ascidian Atriolum robustum: Identification and pharmacological characterization of a unique adenosine derivativeJ. Med. Chem.47(9),2243-2255(2004)

      Oliva, A., Galletti, P., Zappia, V., et al.Studies on substrate specificity of S-adenosylmethionine: Protein-carboxyl methyltransferase from calf brainEur. J. Biochem.104(2),595-602(1980)

      Cole, P.A.Chemical probes for histone-modifying enzymesNat. Chem. Biol.4(10),590-597(2008)

      Lee, S.H., and Cho, Y.D.Induction of apoptosis in leukemia U937 cells by 5'-deoxy-5'-methylthioadenosine, a potent inhibitor of protein carboxylmethyltransferaseExp. Cell Res.240(2),282-292(1998)

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