Cucurbitacin B
Cat. No.：YN373105
CAS No. ：6199-67-3
| 产品名称: | Cucurbitacin B |
| CAS No.: | 6199-67-3 |
| Chemical Name: | (2β,9β,10α,16α,23E)-25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione |
| Synonyms: | 葫芦素 B |
| 分子量: | 558.70 |
| 分子式: | C₃₂H₄₆O₈ |
| SMILES: | O[C@H](C1)[C@@]([C@@](C)(O)C(/C=C/C(OC(C)=O)(C)C)=O)([H])[C@](C2)(C)[C@]1(C)[C@]3([H])CC=C4C(C)(C)C([C@@H](O)C[C@@]4([H])[C@]3(C)C2=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 葫芦素B (Cucurbitacin B)是一具有抗癌活性的天然化合物。 |
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Duangmano, S., Sae-lim, P., Suksamrarn, A., et al.Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocationBMC Complement. Altern. Med.12,185(2012)
Dakeng, S., Duangmano, S., Jiratchariyakul, W., et al.Inhibition of Wnt signaling by cucurbitacin B in breast cancer cells: Reduction of Wnt associated proteins and reduced translocation of falectin-3-mediated ß-catenin to the nucleusJ. Cell. Biochem.113(1),49-60(2012)
Zhang, M., Bian, Z.G., Zhang, Y., et al.Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cellsMol. Med. Rep.10(6),2905-2911(2014)
Gupta, P., and Srivastava, S.K.Inhibition of Integrin-HER2 signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppressionOncotarget5(7),1812-1828(2014)
Kim, M., Park, S.Y., Jin, M.L., et al.Cucurbitacin B inhibits immunomodulatory function and the inflammatory response in macrophagesImmunopharmacol. Immunotoxicol.37(5),473-480(2015)
Dinan, L., Whiting, P., Girault, J.P., et al.Cucurbitacins are insect steroid hormone antagonists acting at the ecdysteroid receptoBiochem. J.327( Pt 3)(Pt 3),643-650(1997)
