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Palmitic acid

Cat. No.:YN373179

  • CAS No. :57-10-3

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    • 生物活性
    • 参考文献
    • 产品名称: Palmitic acid
      CAS No.: 57-10-3
      Chemical Name: hexadecanoic acid
      Synonyms:hexadecanoic acid, Cetylic acid
      分子量:256.42
      分子式:C₁₆H₃₂O₂
      SMILES:CCCCCCCCCCCCCCCC(O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: Palmitic acid 是一种常见于动物和植物中的长链饱和脂肪酸。Palmitic acid 可以诱导小鼠颗粒细胞中葡萄糖调节蛋白 78 (GRP78) 和 CCAAT/增强子结合蛋白同源蛋白 (CHOP) 的表达。
      IC50和靶点:
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    • Fatima, S., Hu, X., Gong, R.-H., et al.Palmitic acid is an intracellular signaling molecule involved in disease developmentCell. Mol. Life Sci.76(13),2547-2557(2019)

      Santos, M.J., López-Jurado, M., Llopis, J., et al.Influence of dietary supplementation with fish oil on plasma fatty acid composition in coronary heart disease patientsAnn. Nutr. Metab.39(1),52-62(1995)

      Binker-Cosen, M.J., Richards, D., Oliver, B., et al.Palmitic acid increases invasiveness of pancreatic cancer cells AsPC-1 through TLR4/ROS/NF-κB/MMP-9 signaling pathwayBiochem. Biophys. Res. Commun.484(1),152-158(2017)

      Lee, J.Y., Sohn, K.H., Rhee, S.H., et al.Saturated fatty acids, but not unsaturated fatty acids, induced the expression of cyclooxygenase-2 mediated through Toll-like receptor 4J. Biol. Chem.276(20),16683-16689(2001)

      Karasawa, T., Kawashima, A., Usui-Kawanishi, F., et al.Saturated fatty acids undergo intracellular crystallization and activate the NLRP3 inflammasome in macrophagesArterioscler. Thromb. Vasc. Biol.38(4),744-756(2018)

      Marwarha, G., Rostad, S., Lilek, J., et al.Palmitate increases β-site AβPP-cleavage enzyme 1 activity and amyloid-β genesis by evoking endoplasmic reticulum stress and subsequent C/EBP homologous protein activationJ. Alzheimers Dis.57(3),907-925(2017)

      Knowles, C.J., Cebova, M., and Pinz, I.M.Palmitate diet-induced loss of cardiac caveolin-3: A novel mechanism for lipid-induced contractile dysfunctionPLoS One8(4),e61369(2013)

      Yi, L.-Z., He, J., Liang, Y.-Z., et al.Plasma fatty acid metabolic profiling and biomarkers of type 2 diabetes mellitus based on GC/MS and PLS-LDAFEBS Lett.580(30),6837-6845(2006)

      Kabagambe, E.K., Tsai, M.Y., Hopkins, P.N., et al.Erythrocyte fatty acid composition and the metabolic syndrome: A National Heart, Lung, and Blood Institute GOLDN studyClin. Chem.54(1),154-162(2008)

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