Glycocholic acid
Cat. No.：YN373202
| 产品名称: | Glycocholic acid |
| CAS No.: | 475-31-0 |
| Chemical Name: | N-[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]-glycine |
| Synonyms: | cholylglycine, Glycocholate |
| 分子量: | 465.62 |
| 分子式: | C₂₆H₄₃NO₆ |
| SMILES: | O=C(O)CNC(CC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Glycocholic acid 是具有抗肿瘤活性的胆汁酸，可靶向作用于耐药泵和非耐药泵通路。 |
| IC50和靶点: | |
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Lefebvre, P., Cariou, B., Lien, F., et al.Role of bile acids and bile acid receptors in metabolic regulationPhysiol. Rev.89(1),147-191(2009)
Guo, C., Xie, C., Ding, P., et al.Quantification of glycocholic acid in human serum by stable isotope dilution ultra performance liquid chromatography electrospray ionization tandem mass spectrometryJ. Chromatogr. B. Analyt. Technol. Biomed. Life Sci.1072,315-319(2018)
Song, W.-S., Park, H.-M., Ha, J.M., et al.Discovery of glycocholic acid and taurochenodeoxycholic acid as phenotypic biomarkers in cholangiocarcinomaSci. Rep.8(1),11088(2018)
Lo, Y.L., Ho, C.T., and Tsai, F.L.Inhibit multidrug resistance and induce apoptosis by using glycocholic acid and epirubicinEur. J. Pharm. Sci.35(1-2),52-67(2008)
