11beta-Hydroxyprogesterone
Cat. No.：YN373275
CAS No. ：600-57-7
| 产品名称: | 11beta-Hydroxyprogesterone |
| CAS No.: | 600-57-7 |
| Chemical Name: | 11β-hydroxy-pregn-4-ene-3,20-dione |
| Synonyms: | 11β-羟孕酮; 11β-Hydroxyprogesterone |
| 分子量: | 330.46 |
| 分子式: | C₂₁H₃₀O₃ |
| SMILES: | C[C@@]12[C@]3([H])[C@](CCC1=CC(CC2)=O)([H])[C@@]4([H])[C@@](C)([C@@H](C(C)=O)CC4)C[C@@H]3O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 11beta-Hydroxyprogesterone是11β-羟基甾类脱氢酶(11β-Hydroxysteroid dehydrogenase)的有效抑制剂; 同时在COS-7细胞中激活人类盐皮质激素受体，ED50值为10 nM。 |
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van Rooyen, D., Gent, R., Barnard, L., et al.The in vitro metabolism of 11β-hydroxyprogesterone and 11-ketoprogesterone to 11-ketodihydrotestosterone in the backdoor pathwayJ. Steroid Biochem. Mol. Biol.178,203-212(2018)
Rafestin-Oblin, M.-E., Fagart, J., Souque, A., et al.11β-hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cellsMol. Pharmacol.62(6),1306-1313(2002)
Souness, G.W., Latif, S.A., Laurenzo, J.L., et al.11α- and 11β-hydroxyprogesterone, potent inhibitors of 11β-hydroxysteroid dehydrogenase (isoforms 1 and 2), confer marked mineralocorticoid activity on corticosterone in the ADX ratEndocrinology136(4),1809-1812(1995)
Souness, G.W., and Morris, D.J.11α- and 11β-hydroxyprogesterone, potent inhibitors of 11β-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the ratHypertension27(3 Pt 1),421-425(1996)
Turcu, A.F., Rege, J., Chomic, R., et al.Profiles of 21-carbon steroids in 21-hydroxylase deficiencyJ. Clin. Endocrinol. Metab.100(6),2283-2290(2015)
