27-Hydroxycholesterol
Cat. No.：YN373283
| 产品名称: | 27-Hydroxycholesterol |
| CAS No.: | 20380-11-4 |
| Chemical Name: | (25R)-cholest-5-ene-3β,26-diol |
| Synonyms: | 27-羟基胆固醇 |
| 分子量: | 402.65 |
| 分子式: | C₂₇H₄₆O₂ |
| SMILES: | C[C@@H](CO)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 27-Hydroxycholesterol是选择性的雌激素受体 (estrogen receptor) 调节剂和肝X 受体 (liver X receptor) 激动剂。 |
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Zhang, Y., and Mangelsdorf, D.J.LuXuRies of lipid homeostasis: The unity of nuclear hormone receptors, transcription regulation, and cholesterol sensingMol. Interv.2(2),78-87(2002)
Fu, X., Menke, J.G., Chen, Y., et al.27-Hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cellsJ. Biol. Chem.276(42),38378-38387(2001)
Axelson, M., and Larsson, O.Low density lipoprotein (LDL) cholesterol is converted to 27-hydroxycholesterol in human fibroblastsJ. Biol. Chem.270(25),15102-15110(1995)
Javitt, N.B.26-Hydroxycholesterol: Synthesis, metabolism, and biologic rolesJ. Lipid Res.31(9),1527-1533(1990)
Javitt, N.B.25R,26-Hydroxycholesterol revisited: Synthesis, metabolism, and biologic rolesJ. Lipid Res.43(5),665-670(2002)
