Cereblon modulator 1
Cat. No.：YN430179
CAS No. ：1860875-51-9
规格
价格(RMB)
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| 产品名称: | Cereblon modulator 1 |
| CAS No.: | 1860875-51-9 |
| Chemical Name: | 4-chloro-N-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-α,α-difluoro-benzeneacetamide |
| Synonyms: | Cereblon modulator 1 |
| 分子量: | 461.85 |
| 分子式: | C₂₂H₁₈ClF₂N₃O₄ |
| SMILES: | O=C(NCC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2)=O)C=C1)C(F)(F)C4=CC=C(Cl)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cereblon modulator 1 (compound F) 是一种cereblon (CRBN)E3 连接酶调节剂。Cereblon modulator 1 与CRBN特异性结合，从而影响泛素 E3 连接酶复合物的活性。 这导致某些底物蛋白的泛素化并诱导蛋白酶体介导的某些转录因子的降解，包括 Ikaros (IKZF1) 和 Aiolos (IKZF3)。 |
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Surka, C., Jin, L., Mbong, M., et al.CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cellsBlood137(5),6610677(2021)
