AZD-5991
Cat. No.：YN270032
CAS No. ：2143061-81-6
| 产品名称: | AZD-5991 |
| CAS No.: | 2143061-81-6 |
| Chemical Name: | (3aR)-5-chloro-2,11,12,24,27,29-hexahydro-2,3,24,33-tetramethyl-22H-9,4,8-(metheniminomethyno)-14,20:26,23-dimetheno-10H,20H-pyrazolo[4,3-l][2,15,22,18,19]benzoxadithiadiazacyclohexacosine-32-carboxylic acid |
| Synonyms: | AZD5991;E3T5XXY9HX;A16880;E4W;17-Chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentazaheptacyclo[27.7.1.14,7.011,15.016,21.020,24.030,35]octatriaconta-1(36),4(38),6,11,14,16,18,20,23,29(37),30,32,34-tridecaene-23-carboxylic acid;US10196404, |
| 分子量: | 672.26 |
| 分子式: | C₃₅H₃₄ClN₅O₃S₂ |
| SMILES: | O=C(O)C1=C(CCCOC2=C(C=CC=C3)C3=CC4=C2)C5=C(N1C)C(C6=C(C)N(C)N=C6CSCC7=NN(C)C(CS4)=C7)=C(Cl)C=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZD-5991 是一种有效的选择性Mcl-1抑制剂，FRET 实验检测的IC50为 0.7 nM， SPR 实验检测的Kd为 0.17 nM。 |
| IC50和靶点: | [{name:"Mcl-1:0.7 nM (IC50)"},{name: "Mcl-1:0.17 nM (Kd)"}] |
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| Solvent & Solubility: |
Tron, A.E., Belmonte, M.A., Adam, A., et al.Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemiaNat. Commun.9(1),5341(2018)
