Piperazine Erastin
Cat. No.：YN270021
CAS No. ：1538593-71-3
规格
价格(RMB)
库存
| 产品名称: | Piperazine Erastin |
| CAS No.: | 1538593-71-3 |
| Chemical Name: | 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[2-(1-methylethoxy)-5-(1-piperazinylmethyl)phenyl]-4(3H)-quinazolinone |
| Synonyms: | |
| 分子量: | 645.19 |
| 分子式: | C₃₅H₄₁ClN₆O₄ |
| SMILES: | O=C1N(C2=CC(CN3CCNCC3)=CC=C2OC(C)C)C(CN4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)=NC6=C1C=CC=C6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Piperazine erastin是erastin的类似物，其诱导铁离子依赖形式的非凋亡性细胞死亡，称为铁死亡。 |
| IC50和靶点: | |
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Larraufie, M.-H., Yang, W.S., Jiang, E., et al.Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubilityBioorg. Med. Chem. Lett.25(21),4787-4792(2015)
Yang, W.S., SriRamaratnam, R., Welsch, M.E., et al.Regulation of ferroptotic cancer cell death by GPX4Cell156(1-2),317-331(2014)
