L-Buthionine-(S,R)-sulfoximine
Cat. No.：YN270070
CAS No. ：83730-53-4
| 产品名称: | L-Buthionine-(S,R)-sulfoximine |
| CAS No.: | 83730-53-4 |
| Chemical Name: | 2S-amino-4-(S-butylsulfonimidoyl)-butanoic acid |
| Synonyms: | L-Buthionine sulfoximine; L-BSO |
| 分子量: | 222.31 |
| 分子式: | C₈H₁₈N₂O₃S |
| SMILES: | N[C@H](C(O)=O)CCS(CCCC)(=O)=N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | L-Buthionine-(S,R)-sulfoximine 是一种具有细胞渗透性的、有效的、快速起效的、不可逆的G-谷氨酸半胱氨酸合成酶 (γ-glutamylcysteine synthetase)抑制剂，可降低细胞内谷胱甘肽的水平，其对黑色素瘤、乳腺卵巢癌标本的IC50值分别为1.9 μM、8.6 μM 和29 μM。 |
| IC50和靶点: | |
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Griffith, O.W.Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesisJ. Biol. Chem.257(22),13704-13712(1982)
Fruehauf, J.P., Zonis, S., al-Bassam, M., et al.Selective and synergistic activity of L-S,R-buthionine sulfoximine on malignant melanoma is accompanied by decreased expression of glutathione-S-transferasePigment Cell Res.10(4),236-249(1997)
Hayashima, K., and Katoh, H.Expression of gamma-glutamyltransferase 1 in glioblastoma cells confers resistance to cystine deprivation-induced ferroptosisJ. Biol. Chem.298(3),101703(2022)
Takahashi, K., Tatsunami, R., Oba, T., et al.Buthionine sulfoximine promotes methylglyoxal-induced apoptotic cell death and oxidative stress in endothelial cellsBiol. Pharm. Bull.33(4),556-560(2010)
Reliene, R., and Schiestl, R.H.Glutathione depletion by buthionine sulfoximine induces DNA deletions in miceCarcinogenesis27(2),240-244(2006)
