iFSP1
Cat. No.：YN270244
CAS No. ：150651-39-1
规格
价格(RMB)
库存
| 产品名称: | iFSP1 |
| CAS No.: | 150651-39-1 |
| Chemical Name: | 1-amino-3-(4-methylphenyl)-pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile |
| Synonyms: | |
| 分子量: | 323.35 |
| 分子式: | C₂₀H₁₃N₅ |
| SMILES: | N#CC1=C(N)N2C3=CC=CC=C3N=C2C(C#N)=C1C4=CC=C(C)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | iFSP1 是FSP1(AIFM2) 的选择性有效抑制剂，EC50值为 103 nM。iFSP1 可选择性地诱导过表达 FSP1 的 GPX4 敲除细胞发生铁死亡 (ferroptosis)。iFSP1 可增强多种人癌细胞系对铁死亡诱导剂的敏感度，如: (1S,3R)-RSL3 (HY-100218A)。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Doll, S., Freitas, F.P., Shah, R., et al.FSP1 is a glutathione-independent ferroptosis suppressorNature575(7784),693-698(2019)
