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Cisplatin

Cat. No.:YN270357

  • CAS No. :15663-27-1

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    • 产品名称: Cisplatin
      CAS No.: 15663-27-1
      Chemical Name: (SP-4-2)-diamminedichloro-platinum
      Synonyms:顺铂; CDDP; cis-Diaminodichloroplatinum
      分子量:300.05
      分子式:Cl₂H₆N₂Pt
      SMILES:Cl[Pt](Cl)([NH3])[NH3]
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Cisplatin (CDDP) 是一种抗肿瘤的化疗剂,它与DNA交联引起癌细胞中 DNA 损伤。Cisplatin 可激活铁死亡 (ferroptosis) 并诱导自噬 (autophagy)。
      IC50和靶点:
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    • Schmitt, S.M., Frezza, M., and Dou, Q.P.New applications of old metal-binding drugs in the treatment of human cancerFront. Biosci. (Schol. Ed.)4,375-391(2012)

      Bose, R.N.Biomolecular targets for platinum antitumor drugsMini. Rev. Med. Chem.2(2),103-111(2002)

      Takahashi, K., Ebihara, K., Honda, Y., et al.Antitumor activity of cis-dichlorodiammineplatinum(II) and its effect on cell cycle progressionGan To Kagaku Ryoho.9(4),624-631(1982)

      Wennerberg, J., Alm, P., Biörklund, A., et al.Cell cycle perturbations in heterotransplanted squamous-cell carcinoma of the head and neck after mitomycin C and Cisplatin treatmentInt. J. Cancer.33(2),213-222(1984)

      Zhang, L., Zheng, Y., Callahan, B., et al.Cisplatin inhibits protein splicing, suggesting inteins as therapeutic targets in mycobacteriaJ. Biol. Chem.286(2),1277-1282(2011)

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