MG-115
Cat. No.：YN270655
CAS No. ：133407-86-0
| 产品名称: | MG-115 |
| CAS No.: | 133407-86-0 |
| Chemical Name: | N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formylbutyl]-L-leucinamide |
| Synonyms: | MG115; MG-115; MG 115; Z-LL-Nva-CHO; ASD 4955; ASD-4955; ASD4955; |
| 分子量: | 461.6 |
| 分子式: | C25H39N3O5 |
| SMILES: | O=C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C([H])=O)CCC)=O)=O)CC(C)C)OCC1=CC=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MG-115 是一种有效和可逆的蛋白酶体抑制剂，对20S和26S蛋白酶体的Ki值分别为 21 nM 和 35 nM。MG-115 特异性抑制蛋白酶体的胰凝乳蛋白酶样活性，诱导 p53 依赖性细胞凋亡。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Rock, K.L., Gramm, C., Rothstein, L., et al.Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I moleculesCell78(5),761-771(1994)
Palombella, V.J., Rando, O.J., Goldberg, A.L., et al.The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κBCell78(5),773-785(1994)
Lopes, U.G., Erhardt, P., Yao, R., et al.p53-dependent induction of apoptosis by proteasome inhibitorsJ. Biol. Chem.272(20),12893-12896(1997)
Bush, K.T., Goldberg, A.L., and Nigam, S.K.Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotoleranceJ. Biol. Chem.272(14),9086-9092(1997)
Gartel, A.L.A new target for proteasome inhibitors: FoxM1Expert Opin. Investig. Drugs19(2),235-242(2010)
