1-Alaninechlamydocin
Cat. No.：YN270661
| 产品名称: | 1-Alaninechlamydocin |
| CAS No.: | 141446-96-0 |
| Chemical Name: | cyclo[L-alanyl-L-phenylalanyl-D-prolyl-(αS,2S)-α-amino-η-oxo-2-oxiraneoctanoyl] |
| Synonyms: | |
| 分子量: | 512.5981 |
| 分子式: | C27H36N4O6 |
| SMILES: | O=C(N[C@@H](CCCCCC([C@@H]1CO1)=O)C(N[C@H]2C)=O)[C@]3([H])N(CCC3)C([C@H](CC4=CC=CC=C4)NC2=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 1-Alaninechlamydocin 是一种环状四肽，是一种有效的HDAC抑制剂 (IC50=6.4 nM)。 1-Alaninechlamydocin 在 MIA PaCa-2 细胞中诱导 G2/M 细胞周期停滞和凋亡 (apoptosis)。 |
| IC50和靶点: | [{name:"HDAC:6.4 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Du, L., Risinger, A.L., King, J.B., et al.A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cellsJ. Nat. Prod.77(7),1753-1757(2014)
