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Ac-YVAD-CHO

Cat. No.:YN270666

  • CAS No. :143313-51-3

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: Ac-YVAD-CHO
      CAS No.: 143313-51-3
      Chemical Name: N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-2-carboxyl-1-formylethyl]-L-alaninamide
      Synonyms:L-709049
      分子量:492.5
      分子式:C23H32N4O8
      SMILES:CC(N([H])[C@@H](CC1=CC=C(O)C=C1)C(N([H])[C@@H](C(C)C)C(N([H])[C@@H](C)C(N([H])[C@@H](CC(O)=O)C([H])=O)=O)=O)=O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Ac-YVAD-CHO (L-709049) 是一种有效的、可逆的、特异性的四肽白介素 1β 转化酶 (ICE) 抑制剂,对小鼠和人类 ICE 的Ki值分别为 3.0 和 0.76 nM。Ac-YVAD-CHO 也是一种caspase-1抑制剂。Ac-YVAD-CHO 可抑制成熟 IL-lβ 的产生。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Chapman, K.T.Synthesis of a potent, reversible inhibitor of interleukin-1β converting enzymeBioorg. Med. Chem. Lett.2(6),613-618(1992)

      Garcia-Calvo, M., Peterson, E.P., Leiting, B., et al.Inhibition of human caspases by peptide-based and macromolecular inhibitorsJ. Biol. Chem.273(49),32608-32613(1998)

      Walsh, J.G., Logue, S.E., Lüthi, A.U., et al.Caspase-1 promiscuity is counterbalanced by rapid inactivation of processed enzymeJ. Biol. Chem.286(37),32513-32524(2011)

      Wang, J., Wang, L., Zhang, X., et al.Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosisInt. Immunopharmacol.94,107496(2021)

      Joshi, V.D., Kalvakolanu, D.V., Hebel, J.R., et al.Role of caspase 1 in murine antibacterial host defenses and lethal endotoxemiaInfect. Immun.70(12),6896-6903(2002)

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