Ac-YVAD-CHO
Cat. No.：YN270666
CAS No. ：143313-51-3
规格
价格(RMB)
库存
| 产品名称: | Ac-YVAD-CHO |
| CAS No.: | 143313-51-3 |
| Chemical Name: | N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-2-carboxyl-1-formylethyl]-L-alaninamide |
| Synonyms: | L-709049 |
| 分子量: | 492.5 |
| 分子式: | C23H32N4O8 |
| SMILES: | CC(N([H])[C@@H](CC1=CC=C(O)C=C1)C(N([H])[C@@H](C(C)C)C(N([H])[C@@H](C)C(N([H])[C@@H](CC(O)=O)C([H])=O)=O)=O)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ac-YVAD-CHO (L-709049) 是一种有效的、可逆的、特异性的四肽白介素 1β 转化酶 (ICE) 抑制剂，对小鼠和人类 ICE 的Ki值分别为 3.0 和 0.76 nM。Ac-YVAD-CHO 也是一种caspase-1抑制剂。Ac-YVAD-CHO 可抑制成熟 IL-lβ 的产生。 |
| IC50和靶点: | |
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Chapman, K.T.Synthesis of a potent, reversible inhibitor of interleukin-1β converting enzymeBioorg. Med. Chem. Lett.2(6),613-618(1992)
Garcia-Calvo, M., Peterson, E.P., Leiting, B., et al.Inhibition of human caspases by peptide-based and macromolecular inhibitorsJ. Biol. Chem.273(49),32608-32613(1998)
Walsh, J.G., Logue, S.E., Lüthi, A.U., et al.Caspase-1 promiscuity is counterbalanced by rapid inactivation of processed enzymeJ. Biol. Chem.286(37),32513-32524(2011)
Wang, J., Wang, L., Zhang, X., et al.Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosisInt. Immunopharmacol.94,107496(2021)
Joshi, V.D., Kalvakolanu, D.V., Hebel, J.R., et al.Role of caspase 1 in murine antibacterial host defenses and lethal endotoxemiaInfect. Immun.70(12),6896-6903(2002)
