PF-543 hydrochloride
Cat. No.：YN270680
| 产品名称: | PF-543 hydrochloride |
| CAS No.: | 1706522-79-3 |
| Chemical Name: | 1-[[4-[[3-methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2R-pyrrolidinemethanol, monohydrochloride |
| Synonyms: | Sphingosine Kinase 1 Inhibitor II hydrochloride |
| 分子量: | 502.06602 |
| 分子式: | C27H31NO4S • HCl |
| SMILES: | O=S(C1=CC=CC=C1)(CC2=CC(OCC3=CC=C(CN4[C@@H](CO)CCC4)C=C3)=CC(C)=C2)=O.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-543 hydrochloride (Sphingosine Kinase 1 Inhibitor II hydrochloride) 是一种有效，选择性，可逆和鞘氨醇竞争性SPHK1抑制剂，IC50为 2 nM，Ki为 3.6 nM。PF-543 hydrochloride 对SPHK1的选择性是SPHK2的 100 倍以上。PF-543 hydrochloride 还是有效的全血中 1-磷酸鞘氨醇 (S1P) 形成的有效抑制剂，IC50为 26.7 nM。PF-543 hydrochloride |
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Schnute, M.E., McReynolds, M.D., Kasten, T., et al.Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1Biochem. J.444(1),79-88(2012)
Zhang, Y., Berka, V., Song, A., et al.Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progressionJ. Clin. Invest.124(6),2750-2761(2014)
