TD52
Cat. No.：YN270684
CAS No. ：1798328-24-1
| 产品名称: | TD52 |
| CAS No.: | 1798328-24-1 |
| Chemical Name: | N2,N3-bis(3-ethynylphenyl)-2,3-quinoxalinediamine |
| Synonyms: | |
| 分子量: | 360.4108 |
| 分子式: | C24H16N4 |
| SMILES: | C#CC1=CC=CC(NC2=NC3=C(N=C2NC4=CC(C#C)=CC=C4)C=CC=C3)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TD52 是 Erlotinib (HY-50896) 衍生物，一种具有口服活性的强效癌性蛋白磷酸酶 2A (CIP2A) 抑制剂。TD52 通过调节 CIP2A/PP2A/p-Akt 信号通路介导三阴性乳腺癌 (TNBC) 细胞的凋亡作用。TD52 通过干扰 Elk1 与 CIP2A 启动子的结合间接减少 CIP2A。TD52 具有小的 p-EGFR 抑制作用并具有抗癌活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Yu, H.-C., Hung, M.-H., Chen, Y.-L., et al.Erlotinib derivative inhibits hepatocellular carcinoma by targeting CIP2A to reactivate protein phosphatase 2ACell Death Dis.5(7),e1359(2014)
Liu, C.-Y., Huang, T.-T., Huang, C.-T., et al.EGFR-independent Elk1/CIP2A signalling mediates apoptotic effect of an erlotinib derivative TD52 in triple-negative breast cancer cellsEur. J. Cancer72,112-123(2017)
