CPI-1189
Cat. No.：YN270687
CAS No. ：183619-38-7
| 产品名称: | CPI-1189 |
| CAS No.: | 183619-38-7 |
| Chemical Name: | 4-(acetylamino)-N-(1,1-dimethylethyl)-benzamide |
| Synonyms: | 4-Acetamido-N-(tert-butyl)benzamide;REN-1189;CPI-1189;4-(acetylamino)-N-tert-butylbenzamide |
| 分子量: | 234.2943 |
| 分子式: | C13H18N2O2 |
| SMILES: | CC(NC1=CC=C(C(NC(C)(C)C)=O)C=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CPI-1189 是一种具有抗氧化和神经保护活性的 TNF-α 释放抑制剂。CPI-1189 可用于HIV相关神经毒性研究，因此 CPI-1189 是HIV相关 CNS 疾病患者神经保护研究的候选活性分子 。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Hensley, K., Robinson, K.A., Pye, Q.N., et al.CPI-1189 inhibits interleukin 1β-induced p38-mitogen-activated protein kinase phosphorylation: An explanation for its neuroprotective properties?Neurosci. Lett.281(2-3),179-182(2000)
Bjugstad, K.B., Flitter, W.D., Garland, W.A., et al.CPI-1189 prevents apoptosis and reduces glial fibrillary acidic protein immunostaining in a TNF-α infusion model for AIDS dementia complexJ. Neurovirol.6(6),478-491(2000)
Bjugstad, K.B., Flitter, W.D., Garland, W.A., et al.Preventive actions of a synthetic antioxidant in a novel animal model of AIDS dementiaBrain Res.795(1-2),349-357(1998)
Greenwood-Van Meerveld, B., and Tyler, K.CPI-1189 protects against TNBS-induced colitis in a rodent modelAm. J. Pharmacol. Toxicol.2(2),30-38(2007)
Greenwood-Van Meerveld, B., and Tyler, K.R.CPI-1189 protects against dextran sulfate sodium-induced colitis in miceAm. J. Pharmacol. Toxicol.1(3),54-59(2006)
