BDA-366
Cat. No.：YN270690
| 产品名称: | BDA-366 |
| CAS No.: | 1909226-00-1 |
| Chemical Name: | 1-[[(2S)-3-(diethylamino)-2-hydroxypropyl]amino]-4-[[(2S)-2-oxiranylmethyl]amino]-9,10-anthracenedione |
| Synonyms: | |
| 分子量: | 423.50488 |
| 分子式: | C24H29N3O4 |
| SMILES: | CCN(CC)C[C@@H](O)CNC(C=C1)=C(C(C2=CC=CC=C2C3=O)=O)C3=C1NC[C@H]4CO4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BDA-366 是一种有效的Bcl2拮抗剂 (Ki= 3.3 nM)，对 Bcl2-BH4 结构域具有较高的亲和力和选择性。BDA-366 诱导 Bcl2 的构象改变，从而消除其抗凋亡功能，将 Bcl2 从存活分子转化为细胞死亡诱导因子。BDA-366 可抑制肺癌细胞生长。 |
| IC50和靶点: | [{name:"Bcl-2:3.3 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Han, B., Park, D., Li, R., et al.Small-molecule Bcl2 BH4 antagonist for lung cancer therapyCancer Cell27(6),852-863(2015)
Vervloessem, T., Sasi, B.K., Xerxa, E., et al.BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell modelsCell Death Dis.11(9),769(2020)
