Diprovocim
Cat. No.:YN270703
CAS No. :2170867-89-5
产品名称: | Diprovocim |
CAS No.: | 2170867-89-5 |
Chemical Name: | (3S,3′S,4S,4′S)-1,1′-(1,4-phenylenedicarbonyl)bis[N-[(1S,2R)-2-phenylcyclopropyl]-3,4-pyrrolidinedicarboxamide |
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分子量: | 909.08068 |
分子式: | C56H56N6O6 |
SMILES: | O=C(C1=CC=C(C=C1)C(N2C[C@@H](C(N[C@@H]3[C@](C4=CC=CC=C4)([H])C3)=O)[C@H](C(N[C@@H]5[C@](C6=CC=CC=C6)([H])C5)=O)C2)=O)N7C[C@@H](C(N[C@@H]8[C@](C9=CC=CC=C9)([H])C8)=O)[C@H](C(N[C@@H]%10[C@](C%11=CC=CC=C%11)([H])C%10)=O)C7 |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | Diprovocim 是一种有效的TLR1/TLR2激动剂。Diprovocim 在人 THP-1 细胞中引发完全激动剂活性 (EC50=110 pM)。Diprovocim 刺激小鼠巨噬细胞释放TNF-α(EC50=1.3 nM)。Diprovocim 激活下游MAPK和NF-κB信号通路。Diprovocim 在小鼠中显示出很强的佐剂活性,尤其是促进细胞免疫反应。 |
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Morin, M.D., Wang, Y., Jones, B.T., et al.Diprovocims: A new and exceptionally potent class of toll-like receptor agonistsJ. Am. Chem. Soc.140(43),14440-14454(2018)
Wang, Y., Su, L., Morin, M.D., et al.Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in miceProc. Natl. Acad. Sci. USA115(37),E8698-E8706(2018)