PARP/PI3K-IN-1
Cat. No.：YN270712
CAS No. ：2337386-47-5
| 产品名称: | PARP/PI3K-IN-1 |
| CAS No.: | 2337386-47-5 |
| Chemical Name: | 4-[[3-[[2-[6-amino-4-(trifluoromethyl)-3-pyridinyl]-5,8-dihydro-4-(4-morpholinyl)pyrido[3,4-d]pyrimidin-7(6H)-yl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone |
| Synonyms: | |
| 分子量: | 660.6211528 |
| 分子式: | C33H28F4N8O3 |
| SMILES: | O=C1C2=CC=CC=C2C(CC3=CC(C(N4CC5=NC(C6=CN=C(N)C=C6C(F)(F)F)=NC(N7CCOCC7)=C5CC4)=O)=C(F)C=C3)=NN1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PARP/PI3K-IN-1 (compound 15) 是一种有效的PARP/PI3K抑制剂，对 PARP-1，PARP-2，PI3Kα，PI3Kβ，PI3Kδ和PI3Kγ的pIC50值分别为 8.22、8.44、8.25、6.54、8.13、6.08。PARP/PI3K-IN-1 是针对多种肿瘤疾病的高效抗癌化合物。 |
| IC50和靶点: | [{name:"PARP-1:8.22 (pIC50)"},{name: "PARP-2:8.44 (pIC50)"},{name: "PI3Kα:8.25 (pIC50)"},{name: "PI3Kδ:8.13 (pIC50)"},{name: "PI3Kγ:6.08 (pIC50)"},{name: "PI3Kβ:6.54 (pIC50)"}] |
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| Solvent & Solubility: |
Wang, J., Li, H., He, G., et al.Discovery of novel dual poly(ADP-ribose)polymerase (PARP) and phosphoinositide 3-kinase (PI3K) inhibitors as a promising strategy for cancer therapyJ. Med. Chem.63(1),122-139(2019)
